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작성자냥이집사 조회 1회 작성일 2020-11-21 23:54:39 댓글 0


COVID-19 and Zinc

President Trump taking zinc (WSJ)


Low zinc levels at clinical admission associates with poor outcomes in COVID-19, (11th October)


Zinc balances immune responses and also has a proven direct antiviral action against some viruses.

Zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases

Increased intracellular zinc concentrations efficiently impair replication

Resulting in a lower number of viruses

Retrospective analysis

Patients admitted in Barcelona

15th March to 30th April 2020

Clinical severity of COVID-19 and PMH assessed

Fasting plasma zinc levels measured routinely at admission

N = 611

Mean age, 63 years

Male 332, (55%)

Total mortality was 87 patients (14%) during study time


249 of 611 patients studied

Of the 249, 21 (8%) died

Baseline zinc levels

Died, (21 people) mean plasma zinc = 43 μg/dl

Survived, (228 people) mean plasma zinc = 63.1 μg/dl

Higher zinc levels, associated with lower maximum levels of interleukin-6 during the period of active infection

Zinc level lower than 50 μg/dl at admission, 2.3 times increased risk of in-hospital death

Compared with those of 50 μg/dl or higher

Lower zinc levels at admission correlate with higher inflammation in the course of infection and poorer outcome

Low plasma zinc levels at admission are associated with mortality in COVID-19 in our study

Further studies are needed to assess the therapeutic impact of this association

COVID-19: Poor outcomes in patients with zinc deficiency (International Journal of Infectious Diseases, November 2020)

Chennai, India

Prospective study of fasting zinc levels in COVID-19 patients at the time of hospitalization

Healthy controls median 105.8 μg/dl


Zinc is a trace element with potent immunoregulatory and antiviral properties

Is utilized in the treatment of coronavirus disease 2019 (COVID-19)

Patients with serious COVID-19 had significantly low zinc levels in comparison to healthy controls

Zinc deficient COVID patients developed more complications

Zinc deficient patients 70.4% developed complications

Non zinc deficient patients, 30.0% developed complications, (p = 0.009)

Acute respiratory distress syndrome

More need of steroids

Increased mortality

Zinc deficient COVID patients had a prolonged hospital stay

Zinc deficient patients, 7.9 days

Non zinc deficient patients, 5.7 days, (p = 0.048)

In vitro studies

Reduced zinc levels increase SARS-CoV-2 virus receptor interactions

Increased zinc levels inhibit ACE2 expression


What zinc does

Catalytic activity of approximately 100 enzymes

Plays a role in immune function

Protein synthesis

Wound healing

DNA synthesis

Cell division

Normal growth and development, pregnancy, childhood, adolescence

Required for sense of taste and smell

Zinc and immunity

Severe zinc deficiency depresses immune function

Even mild to moderate degrees of zinc deficiency can impair macrophage and neutrophil functions, natural killer cell activity, and complement activity

Body requires zinc to develop and activate T-lymphocytes

Low zinc levels have shown reduced lymphocyte proliferation

…. that can be corrected by zinc supplementation

Low zinc status has been associated with increased susceptibility to pneumonia and other infections in children in developing countries and the elderly

Sea food
Baked beans
Fortified cereals
Pumpkin seeds
Cashew nuts

Vitamin D and zinc can be made in bulk for essentially nothing

제70강:몸에 보약같은 미네랄 Zinc 아연 [feat.비타민C 만큼 중요한 이유]

#아연 #비타민 #비타민C #필수 미네랄
아연이 정력제라고? [feat.비타민C 만큼 중요한 이유]
아연은 화학적으로 볼 때 쉽게 전자 2개를 내주어 남은 환원시키고 자신은 산화되는 강력한 항산화 미네랄입니다.
실제로 인체의 1300개의 효소 중 300개 정도는 아연이 코팩터로 작용해야만
작동한다고 알려져 있음으로, 아연이 없으면 인체의 대사가 막대한 지장을 받게 됩니다.
미국과 같은 선진국에서도 성인들의 아연 부족이 10명중 한명이며,
개발도상국가에서 수많은 어린이가 아연 부족을 목숨을 잃고 있습니다.
아연이 부족해 질 때 생기는 임상적 특징과, 진단법 그리고 치료법에 대한
최신 지견을 본 강좌에서 알기 쉽게 요약하였습니다.
특히 감기와 같은 바이러스 질환에서 아연의 효과가 인정되면서,
비타민 씨 못지 않은 면역 증강 작용과 최근 밝혀진 남성 호르몬과 정액 생성에도
아연이 매우 중요한 역활을 한다는 사실이 밝혀지면서,
일반인들도 아연은 단순한 정력제 이상의 매우 중요한 미네날로 인식하고 있습니다.
아연은 생식 기능은 물론이고, 인체의 식욕과 적당한 체중 유지에도 중요하고,
심지어는 인지 기능에도 관연하다고 하니
내가 아연 부족인지 아닌지를 아는 것은 매우 중요합니다.

장항준 종합내과
Ezra Medical Center PC
15009 Northern Blvd Ste A
Flushing, NY 11354

광고, 제휴, 협찬 문의:

Why You Need Zinc

How does Zinc help your body, is 50mg of Zinc too much and should you take Zinc supplements?

#zinc #zincsupplements #zincsulfate

What is Zinc?
Zinc is an essential trace element, which means that the body cannot generate it on its own or store it; it has to come from your diet.

Dietary Sources of Zinc:
• Chicken and other poultry.
• Seafood, particularly shellfish like oysters, crab, mussels and lobster.
• Nuts.
• Grains, beans, lentils and split peas.
• Spinach.
• Dairy products - milk, yoghurt, cheese.
• Fortified breakfast cereal.
• Red meat

Symptoms of Zinc Deficiency:
• Losing weight.
• Not feeling hungry.
• Diarrhoea.
• Having no energy.
• Being more prone to infections, such as colds, coughs and chest infections.
• Losing your hair.
• Skin rashes.
• Problems with eyesight, taste or smell.
• Impotence.
Symptoms in children and adolescents:
• Halting of growth.
• Delayed puberty.
Development of learning difficulty.

Causes of Zinc Deficiency:
• Malnourishment
• Being Vegetarian or Vegan
• Pregnancy \u0026 breastfeeding
• Ulcerative Colitis
• Crohn's Disease
• Coeliac Disease
• Chronic diarrhoea
• Alcohol addiction
• Chronic liver or kidney disease
• Taking high dose iron supplements
• Acrodermatitis enteropathica

Medications that interact with Zinc:
• Penicillamine
• Thiazide diuretics eg Bendrofluazide
• Quinolone and tetracycline antibiotics eg Ciprofloxacin or Doxycycline
Please discuss your medications with your pharmacist if you are unsure.

Zinc Supplement side effects:
• Headaches.
• An unpleasant taste.
• Tummy ache.
• Feeling sick (nausea), or being sick (vomiting).
• Diarrhoea.
• Indigestion.
• Tiredness.
Never take more than the recommended amount, due to the risks of excess zinc.

Cautions of Zinc Supplementation:
• Zinc may accumulate in Acute Kidney Disease
• Those with Haemochromatosis may absorb larger amounts of zinc.
• Excess zinc supplementation can interfere with iron and copper absorption.
• It can also reduce magnesium and calcium absorption.

Medical References \u0026 Papers:
1. The accuracy of the Zinc Taste Test method. J Altern Complement Med 2012 Jun;18(6):541-50. https://pubmed.ncbi.nlm.nih.gov/22784341/
2. Zinc for the common cold. Cochrane Database Syst Rev. 2015 Apr; 2015(4): CD001364. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457799/
3. The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatol Ther (Heidelb). 2019 Mar; 9(1): 51–70. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380979/

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